SLAMF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPRC
Gene Ontology Biological Process
- B cell proliferation [ISS]
- B cell receptor signaling pathway [ISS]
- T cell differentiation [ISS]
- T cell receptor signaling pathway [IDA, TAS]
- axon guidance [TAS]
- bone marrow development [IMP]
- cell cycle phase transition [IMP]
- cell surface receptor signaling pathway [TAS]
- defense response to virus [ISS]
- dephosphorylation [ISS]
- hematopoietic progenitor cell differentiation [IMP]
- immunoglobulin biosynthetic process [IMP]
- negative regulation of T cell mediated cytotoxicity [ISS]
- negative regulation of cell adhesion involved in substrate-bound cell migration [IMP]
- negative regulation of cytokine-mediated signaling pathway [ISS]
- negative regulation of protein kinase activity [IDA, ISS]
- peptidyl-tyrosine dephosphorylation [IDA, TAS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of T cell proliferation [ISS]
- positive regulation of antigen receptor-mediated signaling pathway [ISS]
- positive regulation of hematopoietic stem cell migration [IMP]
- positive regulation of protein kinase activity [NAS]
- positive regulation of stem cell proliferation [IMP]
- protein dephosphorylation [ISS]
- regulation of cell cycle [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- stem cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.
CDw150, a receptor up-regulated on activated T or B lymphocytes, has a key role in regulating B cell proliferation. Patients with X-linked lymphoproliferative disease have mutations in a gene encoding a protein, DSHP/SAP, which interacts with CDw150 and is expressed in B cells. Here we show that CDw150 on B cells associates with two tyrosine-phosphorylated proteins, 59 kDa and 145 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID