VMP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP2A2
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion import into sarcoplasmic reticulum [IC, ISS]
- calcium ion transmembrane transport [IDA]
- calcium ion transport from cytosol to endoplasmic reticulum [IDA]
- cell adhesion [TAS]
- cellular calcium ion homeostasis [IDA]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- epidermis development [TAS]
- ion transmembrane transport [TAS]
- positive regulation of endoplasmic reticulum calcium ion concentration [IDA]
- positive regulation of heart rate [TAS]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISS]
- regulation of cardiac muscle cell membrane potential [IC, ISS, TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IDA]
- relaxation of cardiac muscle [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA, TAS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA]
- longitudinal sarcoplasmic reticulum [IDA]
- membrane [IDA]
- platelet dense tubular network membrane [TAS]
- sarcoplasmic reticulum [IDA]
- sarcoplasmic reticulum membrane [IC, TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P contributes to the formation of ER-IM contacts, and ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATP2A2 VMP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 3019574 |
Curated By
- BioGRID