DGAT2
Gene Ontology Biological Process
- acylglycerol acyl-chain remodeling [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to oleic acid [ISS]
- cellular triglyceride homeostasis [ISS]
- cholesterol homeostasis [ISS]
- diacylglycerol metabolic process [IDA]
- fat pad development [ISS]
- fatty acid homeostasis [ISS]
- glycerophospholipid biosynthetic process [TAS]
- lipid storage [ISS]
- long-chain fatty-acyl-CoA metabolic process [IDA]
- low-density lipoprotein particle clearance [ISS]
- phospholipid metabolic process [TAS]
- regulation of plasma lipoprotein particle levels [ISS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC27A1
Gene Ontology Biological Process
- cardiolipin biosynthetic process [IMP]
- cellular lipid metabolic process [TAS]
- long-chain fatty acid transport [TAS]
- negative regulation of phospholipid biosynthetic process [IMP]
- phosphatidic acid biosynthetic process [IMP]
- phosphatidylcholine biosynthetic process [IMP]
- phosphatidylethanolamine biosynthetic process [IMP]
- phosphatidylglycerol biosynthetic process [IMP]
- phosphatidylinositol biosynthetic process [IMP]
- phosphatidylserine biosynthetic process [IMP]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P contributes to the formation of ER-IM contacts, and ... [more]
Throughput
- Low Throughput
Additional Notes
- Sources of DGAT2 and FATP1/SLC27A1 not clear
Curated By
- BioGRID