BAIT
RAB15
RAB15, member RAS oncogene family
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Rab protein signal transduction [IBA]
- intracellular protein transport [IBA]
- positive regulation of regulated secretory pathway [IGI, IMP]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RABIF
MSS4, RASGFR3, RASGRF3
RAB interacting factor
GO Process (2)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.
Rab15 is a novel endocytic Rab that counters the stimulatory effect of Rab5-GTP on early endocytic trafficking. Rab15 may interfere with Rab5 function directly by sequestering Rab5 effectors or indirectly through novel sets of effector interactions. To distinguish between these possibilities, we examined the effector binding properties of Rab15. Rab15 does not interact directly with the Rab5 effectors rabex-5 and ... [more]
J. Biol. Chem. Sep. 06, 2002; 277(36);32722-9 [Pubmed: 12105226]
Throughput
- Low Throughput
Curated By
- BioGRID