MAML1
Gene Ontology Biological Process
- Notch signaling pathway [IDA, TAS]
- atrioventricular node cell development [ISS]
- atrioventricular node development [ISS]
- gene expression [TAS]
- positive regulation of myotube differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein phosphorylation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NOTCH4
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [TAS]
- cell differentiation [NAS]
- cell fate determination [TAS]
- embryo development [ISS]
- gene expression [TAS]
- hemopoiesis [TAS]
- mammary gland development [IDA]
- morphogenesis of a branching structure [ISS]
- negative regulation of cell differentiation [NAS]
- negative regulation of endothelial cell differentiation [ISS]
- patterning of blood vessels [ISS]
- positive regulation of transcription of Notch receptor target [TAS]
- positive regulation of transcription, DNA-templated [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs and humans. In Drosophila melanogaster , loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells. Upon ligand activation, the intracellular domain of Notch (ICN) translocates to the nucleus, and interacts directly with the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID