BAIT

DDX39A

BAT1, BAT1L, DDX39, DDXL, URH49
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

VAMP4

VAMP-4, VAMP24, RP4-560B9.3
vesicle-associated membrane protein 4
Homo sapiens

Affinity Capture-RNA

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Publication

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

Shi P, Guo Y, Su Y, Zhu M, Fu Y, Chi H, Wu J, Huang J

The RNA helicase DDX39A plays an important role in the RNA splicing/export process. In our study, human DDX39A facilitated RNA virus escape from innate immunity to promote virus proliferation by trapping TRAF3, TRAF6, and MAVS mRNAs in the HEK293T cell nucleus. DDX39A was a target for SUMOylation. SUMO1, 2, and 3 modifications were found on immunoprecipitated DDX39A. However, only the ... [more]

J Immunol Dec. 01, 2019; 205(1);168-180 [Pubmed: 32393512]

Quantitative Score

  • 5.140794286 [FoldChange]

Throughput

  • High Throughput

Additional Notes

  • Affinity capture-RNA was carried out to identify high-confidence protein-RNA interactions with a Fold Change over control immuniprecipitation > 2.0 (Fold change reported here)

Curated By

  • BioGRID