BAIT
DDX39A
BAT1, BAT1L, DDX39, DDXL, URH49
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRIM38
RNF15, RORET
tripartite motif containing 38
GO Process (5)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of viral entry into host cell [IDA]
- signal transduction [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.
The RNA helicase DDX39A plays an important role in the RNA splicing/export process. In our study, human DDX39A facilitated RNA virus escape from innate immunity to promote virus proliferation by trapping TRAF3, TRAF6, and MAVS mRNAs in the HEK293T cell nucleus. DDX39A was a target for SUMOylation. SUMO1, 2, and 3 modifications were found on immunoprecipitated DDX39A. However, only the ... [more]
J Immunol Dec. 01, 2019; 205(1);168-180 [Pubmed: 32393512]
Quantitative Score
- 4.277427736 [FoldChange]
Throughput
- High Throughput
Additional Notes
- Affinity capture-RNA was carried out to identify high-confidence protein-RNA interactions with a Fold Change over control immuniprecipitation > 2.0 (Fold change reported here)
Curated By
- BioGRID