An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

BPA modulates the WDR5/TET2 complex to regulate ER? expression in eutopic endometrium and drives the development of endometriosis.

Xue W, Yao X, Ting G, Ling J, Huimin L, Yuan Q, Chun Z, Ming Z, Yuanzhen Z

Overexpression of estrogen receptor ? (ER?) in endometrium contributes to endometriosis (EM) pathogenesis. Trimethylation of the H3 lysine (K) 4 (H3K4me3) in promoters is strongly correlated with gene expression. This study aimed to explore the effects of bisphenol A (BPA) exposure on EM development from the perspective of the regulation of ER? expression in eutopic endometrium via the H3K4me3-related epigenetic ... [more]

Environ Pollut Jan. 01, 2021; 268(Pt B);115748 [Pubmed: 33022573]

Quantitative Score

273.0 [Mascot Score]

Throughput

High Throughput

Additional Notes

Affinity capture-MS was carried out to identify high-confidence protein interactions. Mascot Scores are reported here.

Curated By

BioGRID

Interaction Summary

WDR5

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone acetyltransferase activity (H4-K16 specific) [IDA]histone acetyltransferase activity (H4-K5 specific) [IDA]histone acetyltransferase activity (H4-K8 specific) [IDA]histone methyltransferase activity (H3-K4 specific) [IDA]protein binding [IPI]

Gene Ontology Cellular Component

SLC3A2

Gene Ontology Biological Process

Gene Ontology Molecular Function

calcium:sodium antiporter activity [TAS]double-stranded RNA binding [IDA]neutral amino acid transmembrane transporter activity [ISS]poly(A) RNA binding [IDA]protein binding [IPI]