WDR5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB1A
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IGI, IMP]
- GTP catabolic process [IDA]
- Golgi organization [IMP]
- Rab protein signal transduction [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- cargo loading into COPII-coated vesicle [IMP]
- cell migration [IMP]
- cilium assembly [IMP]
- defense response to bacterium [IMP]
- endocytosis [IMP]
- growth hormone secretion [IMP]
- interleukin-8 secretion [IMP]
- intracellular protein transport [IBA]
- mitotic cell cycle [TAS]
- positive regulation of glycoprotein metabolic process [IGI]
- vesicle transport along microtubule [IMP]
- vesicle-mediated transport [TAS]
- virion assembly [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BPA modulates the WDR5/TET2 complex to regulate ER? expression in eutopic endometrium and drives the development of endometriosis.
Overexpression of estrogen receptor ? (ER?) in endometrium contributes to endometriosis (EM) pathogenesis. Trimethylation of the H3 lysine (K) 4 (H3K4me3) in promoters is strongly correlated with gene expression. This study aimed to explore the effects of bisphenol A (BPA) exposure on EM development from the perspective of the regulation of ER? expression in eutopic endometrium via the H3K4me3-related epigenetic ... [more]
Quantitative Score
- 187.0 [Mascot Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture-MS was carried out to identify high-confidence protein interactions. Mascot Scores are reported here.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WDR5 RAB1A | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3446698 |
Curated By
- BioGRID