BAIT
PAGE4
CT16.7, GAGE-9, GAGEC1, JM-27, PAGE-1, PAGE-4, JM27
P antigen family, member 4 (prostate associated)
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ADAR
ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136, RP11-61L14.5
adenosine deaminase, RNA-specific
GO Process (15)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, TAS]
- base conversion or substitution editing [IDA]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA modification [TAS]
- miRNA loading onto RISC involved in gene silencing by miRNA [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA, IMP]
- positive regulation of viral genome replication [IDA, IMP]
- pre-miRNA processing [IDA]
- protein export from nucleus [IDA]
- protein import into nucleus [IDA]
- response to interferon-alpha [IDA]
- response to virus [IMP]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Tissue-Specific Regulation of the Wnt/?-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Spatiotemporal control of Wnt/?-catenin signaling is critical for organism development and homeostasis. The poly-(ADP)-ribose polymerase Tankyrase (TNKS1) promotes Wnt/?-catenin signaling through PARylation-mediated degradation of AXIN1, a component of the ?-catenin destruction complex. Although Wnt/?-catenin is a niche-restricted signaling program, tissue-specific factors that regulate TNKS1 are not known. Here, we report prostate-associated gene 4 (PAGE4) as a tissue-specific TNKS1 inhibitor that ... [more]
Cell Rep Dec. 21, 2019; 32(3);107922 [Pubmed: 32698014]
Throughput
- High Throughput
Curated By
- BioGRID