NCKAP1L
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell receptor signaling pathway [IMP]
- T cell homeostasis [ISS]
- actin polymerization-dependent cell motility [IMP]
- chemotaxis [IDA]
- cortical actin cytoskeleton organization [IMP]
- erythrocyte development [IEP]
- maintenance of cell polarity [IMP]
- myeloid cell homeostasis [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of myosin-light-chain-phosphatase activity [IMP]
- neutrophil chemotaxis [IDA]
- positive regulation of B cell differentiation [ISS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of CD4-positive, alpha-beta T cell differentiation [ISS]
- positive regulation of CD8-positive, alpha-beta T cell differentiation [ISS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of T cell proliferation [ISS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of erythrocyte differentiation [ISS]
- positive regulation of gamma-delta T cell differentiation [ISS]
- positive regulation of lymphocyte differentiation [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of phagocytosis, engulfment [ISS]
- positive regulation of phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- protein complex assembly [ISS]
- response to drug [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WASF2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.
Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity, lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level. We describe five patients from four families with immunodeficiency coupled with atopy, lymphoproliferation, and cytokine overproduction harboring mutations in NCKAP1L, which encodes the hematopoietic-specific HEM1 protein. These mutations cause the loss of the HEM1 protein and the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID