BAIT
MAP4K2
BL44, GCK, RAB8IP
mitogen-activated protein kinase kinase kinase kinase 2
GO Process (6)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ZC3HAV1
ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, PRO1677
zinc finger CCCH-type, antiviral 1
GO Process (7)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of RIG-I signaling pathway [IMP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta production [IDA]
- positive regulation of mRNA catabolic process [IDA]
- response to virus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.
Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) constitute a mammalian STE20-like serine/threonine kinase subfamily. Recent studies provide substantial evidence for MAP4K family kinases in the Hippo pathway regulation, suggesting a broad role of MAP4Ks in human physiology and diseases. However, a comprehensive analysis of the regulators and effectors for this key kinase family has not been fully achieved. Using a ... [more]
Cell Rep Dec. 07, 2019; 32(1);107860 [Pubmed: 32640226]
Throughput
- Low Throughput
Curated By
- BioGRID