BAIT

MAP4K4

FLH21957, HEL-S-31, HGK, MEKKK4, NIK
mitogen-activated protein kinase kinase kinase kinase 4
Homo sapiens
PREY

CTTNBP2

C7orf8, CORTBP2, Orf4
cortactin binding protein 2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.

Seo G, Han H, Vargas RE, Yang B, Li X, Wang W

Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) constitute a mammalian STE20-like serine/threonine kinase subfamily. Recent studies provide substantial evidence for MAP4K family kinases in the Hippo pathway regulation, suggesting a broad role of MAP4Ks in human physiology and diseases. However, a comprehensive analysis of the regulators and effectors for this key kinase family has not been fully achieved. Using a ... [more]

Cell Rep Dec. 07, 2019; 32(1);107860 [Pubmed: 32640226]

Throughput

  • Low Throughput

Curated By

  • BioGRID