BAIT
SLC6A3
DAT, DAT1, PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TGFB1I1
ARA55, HIC-5, HIC5, TSC-5
transforming growth factor beta 1 induced transcript 1
GO Process (9)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- cell adhesion [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.
The Na+/Cl--dependent dopamine transporter (DAT) is critical in terminating dopaminergic transmission by removing the transmitter away from the synapse. Several lines of evidence suggest that transporter-interacting proteins may play a role in DAT function and regulation. In this report, using the yeast two-hybrid system, we have identified a novel interaction between DAT and the multiple Lin-11, Isl-1, and Mec-3 (LIM) ... [more]
J. Neurosci. Aug. 15, 2002; 22(16);7045-54 [Pubmed: 12177201]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC6A3 TGFB1I1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID