BAIT
NUDCD2
NudC domain containing 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNA12
NNX3, RMP, gep
guanine nucleotide binding protein (G protein) alpha 12
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- Rho protein signal transduction [IBA]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- platelet activation [TAS]
- regulation of TOR signaling [IMP]
- regulation of fibroblast migration [ISS]
- regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.
Cell migration plays pivotal roles in many biological processes; however, its underlying mechanism remains unclear. Here, we find that NudC-like protein 2 (NudCL2), a cochaperone of heat shock protein 90 (Hsp90), modulates cell migration by stabilizing both myosin-9 and lissencephaly protein 1 (LIS1). Either knockdown or knockout of NudCL2 significantly increases single-cell migration, but has no significant effect on collective ... [more]
Cell Death Dis Dec. 14, 2019; 11(7);534 [Pubmed: 32665550]
Throughput
- High Throughput
Curated By
- BioGRID