BAIT
NUDCD2
NudC domain containing 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PKD1
PBP, Pc-1, TRPP1
polycystic kidney disease 1 (autosomal dominant)
GO Process (34)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- anatomical structure morphogenesis [TAS]
- branching morphogenesis of an epithelial tube [IDA]
- calcium ion transmembrane transport [ISS]
- calcium-independent cell-matrix adhesion [TAS]
- cartilage development [IEP]
- cell cycle arrest [ISS]
- cell-matrix adhesion [TAS]
- cytoplasmic sequestering of transcription factor [ISS]
- detection of mechanical stimulus [IBA, ISS]
- digestive tract development [IEP]
- embryonic placenta development [ISS]
- genitalia development [IEP]
- heart development [IEP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- lung epithelium development [IEP]
- mesonephric duct development [IEP]
- mesonephric tubule development [IEP]
- metanephric ascending thin limb development [IEP]
- metanephric collecting duct development [IEP]
- metanephric distal tubule morphogenesis [IEP]
- metanephric proximal tubule development [IEP]
- neural tube development [IEP]
- peptidyl-serine phosphorylation [ISS]
- placenta blood vessel development [ISS]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of protein binding [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein export from nucleus [ISS]
- regulation of proteasomal protein catabolic process [IDA]
- skin development [IEP]
- spinal cord development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.
Cell migration plays pivotal roles in many biological processes; however, its underlying mechanism remains unclear. Here, we find that NudC-like protein 2 (NudCL2), a cochaperone of heat shock protein 90 (Hsp90), modulates cell migration by stabilizing both myosin-9 and lissencephaly protein 1 (LIS1). Either knockdown or knockout of NudCL2 significantly increases single-cell migration, but has no significant effect on collective ... [more]
Cell Death Dis Dec. 14, 2019; 11(7);534 [Pubmed: 32665550]
Throughput
- High Throughput
Curated By
- BioGRID