TLR4
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T-helper 1 type immune response [NAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to mechanical stimulus [IEP]
- defense response to Gram-negative bacterium [IC]
- defense response to bacterium [TAS]
- detection of fungus [NAS]
- detection of lipopolysaccharide [IDA]
- immune response [TAS]
- innate immune response [TAS]
- intestinal epithelial structure maintenance [ISS]
- lipopolysaccharide-mediated signaling pathway [IDA, IGI]
- macrophage activation [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-23 production [ISS]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of osteoclast differentiation [NAS]
- negative regulation of tumor necrosis factor production [ISS]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha production [ISS]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 production [ISS]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of platelet activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of tumor necrosis factor production [ISS]
- response to lipopolysaccharide [IC, IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OPA1
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- axon transport of mitochondrion [TAS]
- cellular senescence [IDA]
- inner mitochondrial membrane organization [IDA]
- mitochondrial fission [TAS]
- mitochondrial fusion [IDA, IMP, TAS]
- mitochondrial genome maintenance [IMP]
- mitochondrion organization [IMP, NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.
Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated. Furthermore, the mechanism of Selene targeting mitochondria of tumor cells were also investigated. Methods: Selene were synthesized and characterized ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID