BAIT
EFS
embryonal Fyn-associated substrate
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
PREY
PTK2B
CAKB, CAKbeta, Pyk2
protein tyrosine kinase 2 beta
GO Process (88)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- actin filament organization [IMP]
- activation of Janus kinase activity [IMP, ISO]
- activation of Rac GTPase activity [IMP]
- angiogenesis [IMP]
- blood vessel endothelial cell migration [IMP]
- bone resorption [ISO, ISS]
- cell adhesion [IMP]
- cell differentiation [IEP]
- cell surface receptor signaling pathway [ISO, ISS]
- cellular defense response [IMP]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IMP]
- focal adhesion assembly [IMP]
- glial cell proliferation [IEP]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IMP]
- long-term synaptic potentiation [IMP]
- marginal zone B cell differentiation [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of bone mineralization [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of ossification [IMP]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [IMP]
- oocyte maturation [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell chemotaxis [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [IEP, ISO]
- positive regulation of cell-matrix adhesion [ISO, ISS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of actin cytoskeleton reorganization [ISO, ISS]
- regulation of cGMP biosynthetic process [ISO]
- regulation of cGMP-mediated signaling [ISO]
- regulation of calcium-mediated signaling [ISO]
- regulation of cell adhesion [IBA, ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of establishment of cell polarity [ISO, ISS]
- regulation of inositol trisphosphate biosynthetic process [ISO, ISS]
- regulation of macrophage chemotaxis [ISO, ISS]
- regulation of nitric oxide biosynthetic process [ISO]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO, ISS]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hormone [IEP]
- response to hydrogen peroxide [IPI]
- response to hypoxia [IEP]
- response to immobilization stress [IEP]
- response to lithium ion [IEP]
- response to mechanical stimulus [IEP]
- response to organonitrogen compound [IEP]
- response to osmotic stress [IEP]
- response to reactive oxygen species [IEP]
- sprouting angiogenesis [ISO, ISS]
- stress fiber assembly [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, IMP]
- apical dendrite [IDA]
- axon [IDA]
- cell body [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- dendrite [IDA]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- growth cone [IDA]
- lamellipodium [ISO, ISS]
- membrane raft [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.
The Src homology 3 (SH3) domains are a modular structure of about 60 amino acid residues found in many proteins important in signal transduction. Each SH3 domain has a binding specificity to sequences containing a PXXP motif in ligand proteins. We found that a focal adhesion kinase (FAK)-related protein, cell adhesion kinase beta (CAKbeta), was bound in vitro by the ... [more]
Anal. Biochem. Sep. 10, 1998; 262(2);185-92 [Pubmed: 9750131]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID