SEM1
Gene Ontology Biological Process
- SAGA complex localization to transcription regulatory region [IMP]
- exocytosis [IGI, IPI]
- filamentous growth [IMP]
- histone deubiquitination [IMP]
- mRNA export from nucleus [IGI, IMP, IPI]
- maintenance of DNA trinucleotide repeats [IMP]
- proteasome assembly [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA, IMP]
- regulation of cell cycle [IMP]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Cellular Component
STS1
Gene Ontology Biological Process
Dosage Growth Defect
A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
Publication
The Sts1 nuclear import adapter uses a non-canonical bipartite nuclear localization signal and is directly degraded by the proteasome.
The proteasome is an essential regulator of protein homeostasis. In yeast and many mammalian cells, proteasomes strongly concentrate in the nucleus. Sts1 from the yeast Saccharomyces cerevisiae is an essential protein linked to proteasome nuclear localization. Here, we show that Sts1 contains a non-canonical bipartite nuclear localization signal (NLS) important for both nuclear localization of Sts1 itself and the proteasome. ... [more]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SEM1 STS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3317 | BioGRID | 2036577 |
Curated By
- BioGRID