HOOK3
Gene Ontology Biological Process
- Golgi localization [IMP]
- cytoplasmic microtubule organization [IMP]
- early endosome to late endosome transport [IMP]
- endosome organization [IMP]
- endosome to lysosome transport [IMP]
- interkinetic nuclear migration [ISS]
- lysosome organization [IMP]
- microtubule anchoring at centrosome [ISS]
- negative regulation of neurogenesis [ISS]
- protein localization to centrosome [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HOOK3
Gene Ontology Biological Process
- Golgi localization [IMP]
- cytoplasmic microtubule organization [IMP]
- early endosome to late endosome transport [IMP]
- endosome organization [IMP]
- endosome to lysosome transport [IMP]
- interkinetic nuclear migration [ISS]
- lysosome organization [IMP]
- microtubule anchoring at centrosome [ISS]
- negative regulation of neurogenesis [ISS]
- protein localization to centrosome [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.
The heterotetrameric adaptor protein complex 4 (AP-4) is a component of a protein coat associated with the trans-Golgi network (TGN). Mutations in AP-4 subunits cause a complicated form of autosomal-recessive hereditary spastic paraplegia termed AP-4-deficiency syndrome. Recent studies showed that AP-4 mediates export of the transmembrane autophagy protein ATG9A from the TGN to preautophagosomal structures. To identify additional proteins that ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HOOK3 HOOK3 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - | |
HOOK3 HOOK3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID