BAIT
CTNNB1
CTNNB, MRD19, armadillo, OK/SW-cl.35
catenin (cadherin-associated protein), beta 1, 88kDa
GO Process (48)
GO Function (20)
GO Component (23)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- adherens junction assembly [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISS]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell adhesion [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to growth factor stimulus [IMP]
- cellular response to indole-3-methanol [IDA]
- embryonic skeletal limb joint morphogenesis [ISS]
- endothelial tube morphogenesis [IMP]
- epithelial to mesenchymal transition [TAS]
- hair cell differentiation [TAS]
- innate immune response [TAS]
- muscle cell differentiation [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of mitotic cell cycle, embryonic [ISS]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- patterning of blood vessels [IC]
- positive regulation of DNA-templated transcription, initiation [IC]
- positive regulation of apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IGI]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of histone H3-K4 methylation [IC]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- protein localization to cell surface [IMP]
- regulation of angiogenesis [TAS]
- regulation of calcium ion import [IDA]
- regulation of cell fate specification [IBA]
- regulation of centriole-centriole cohesion [IDA]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of fibroblast proliferation [TAS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- regulation of protein localization to cell surface [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- response to drug [IEP]
- response to estradiol [IDA]
- single organismal cell-cell adhesion [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [ISS]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- adherens junction [IDA]
- beta-catenin destruction complex [IDA]
- beta-catenin-TCF7L2 complex [IDA]
- catenin complex [IDA]
- cell cortex [IDA]
- cell junction [IDA, TAS]
- cell periphery [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- lateral plasma membrane [IDA]
- membrane [ISS]
- nuclear euchromatin [IDA]
- nucleoplasm [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- protein-DNA complex [IDA]
- transcription factor complex [IDA]
Homo sapiens
PREY
TCF7L1
TCF-3, TCF3
transcription factor 7-like 1 (T-cell specific, HMG-box)
GO Process (7)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystal structure of a beta-catenin/Tcf complex.
The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel ... [more]
Cell Dec. 08, 2000; 103(6);885-96 [Pubmed: 11136974]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTNNB1 TCF7L1 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID