F10
Gene Ontology Biological Process
- blood coagulation [IC, TAS]
- blood coagulation, extrinsic pathway [TAS]
- blood coagulation, intrinsic pathway [TAS]
- cellular protein metabolic process [TAS]
- peptidyl-glutamic acid carboxylation [TAS]
- positive regulation of cell migration [TAS]
- positive regulation of protein kinase B signaling [IDA]
- post-translational protein modification [TAS]
- proteolysis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLAT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Binding of plasminogen and tissue plasminogen activator to plasmin-modulated factor X and factor Xa.
Previous work in our laboratory has suggested that the fibrinolytic enzyme plasmin (Pn) inactivates coagulation factors X (FX) and Xa (FXa) in the presence of Ca(2+) and anionic phospholipid (aPL), producing fragments which bind plasminogen (Pg) and accelerate tissue plasminogen activator (t-PA). Our goals here were to determine if the Pn-mediated fragments of FX or FXa remain associated, whether they ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID