BAIT
ATF6
ATF6A
activating transcription factor 6
GO Process (9)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [TAS]
- protein folding [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- response to stress [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATF6B
CREB-RP, CREBL1, G13, DADB-220I18.4
activating transcription factor 6 beta
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.
The levels of molecular chaperones and folding enzymes in the endoplasmic reticulum (ER) are controlled by a transcriptional induction process termed the unfolded protein response (UPR). The mammalian UPR is mediated by the cis-acting ER stress response element (ERSE), the consensus sequence of which is CCAAT-N(9)-CCACG. We recently proposed that ER stress response factor (ERSF) binding to ERSE is a ... [more]
Mol. Cell. Biol. Feb. 01, 2001; 21(4);1239-48 [Pubmed: 11158310]
Throughput
- Low Throughput
Curated By
- BioGRID