VDAC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCL2L11
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [IMP, TAS]
- positive regulation of fibroblast apoptotic process [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IMP, TAS]
- positive regulation of protein homooligomerization [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of release of cytochrome c from mitochondria [IGI, IMP]
- response to endoplasmic reticulum stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim.
Bcl-2 family of proteins regulates apoptosis by controlling mitochondrial membrane permeability. We have previously shown that the voltage-dependent anion channel (VDAC) plays a crucial role in apoptotic changes of the mitochondria and its activity is directly regulated by some Bcl-2 family members, including Bcl-2/Bcl-x(L) and Bax/Bak but not Bid. Here, we showed that in isolated mitochondria, Bim induced loss of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID