BAIT
HMGB1
HMG1, HMG3, SBP-1, RP11-550P23.1
high mobility group box 1
GO Process (22)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- DNA ligation involved in DNA repair [ISS]
- DNA recombination [ISS]
- DNA topological change [ISS]
- V(D)J recombination [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- base-excision repair, DNA ligation [IDA]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- chromatin remodeling [IBA]
- dendritic cell chemotaxis [ISS]
- inflammatory response to antigenic stimulus [IEP]
- innate immune response [TAS]
- myeloid dendritic cell activation [ISS]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neuron projection development [ISS]
- positive chemotaxis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding, bending [IMP, ISS]
- RAGE receptor binding [ISS]
- chemoattractant activity [ISS]
- chromatin binding [IBA]
- cytokine activity [ISS]
- damaged DNA binding [ISS]
- double-stranded DNA binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [ISS]
- transcription factor binding [IPI]
- DNA binding, bending [IMP, ISS]
- RAGE receptor binding [ISS]
- chemoattractant activity [ISS]
- chromatin binding [IBA]
- cytokine activity [ISS]
- damaged DNA binding [ISS]
- double-stranded DNA binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [ISS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
C1QA
complement component 1, q subcomponent, A chain
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response.
High mobility group box B (HMGB) proteins are overexpressed in different types of cancers such as epithelial ovarian cancers (EOC). We have determined the first interactome of HMGB1 and HMGB2 in epithelial ovarian cancer (the EOC-HMGB interactome). Libraries from the SKOV-3 cell line and a primary transitional cell carcinoma (TCC) ovarian tumor were tested by the Yeast Two Hybrid (Y2H) ... [more]
Cancers (Basel) Aug. 27, 2020; 12(9); [Pubmed: 32867128]
Throughput
- Low Throughput
Curated By
- BioGRID