BAIT
CHD4
CHD-4, Mi-2b, Mi2-BETA
chromodomain helicase DNA binding protein 4
GO Process (3)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [TAS]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- ATP-dependent DNA helicase activity [TAS]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
DPYSL5
CRAM, CRMP-5, CRMP5, Ulip6
dihydropyrimidinase-like 5
GO Process (3)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.
The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitive to CHD4 amongst the NuRD members. Mechanistically, NuRD complex containing CHD4 localizes to super-enhancers where CHD4 generates a chromatin architecture permissive for the binding of the tumor driver ... [more]
Elife Dec. 03, 2019; 9(); [Pubmed: 32744500]
Throughput
- Low Throughput
Curated By
- BioGRID