ANGPT1
Gene Ontology Biological Process
- Tie signaling pathway [IDA]
- activation of transmembrane receptor protein tyrosine kinase activity [IDA]
- blood coagulation [TAS]
- glomerulus vasculature development [ISS]
- heparin biosynthetic process [IDA]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of vascular permeability [IDA]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of receptor internalization [IDA]
- protein localization to cell surface [IDA]
- regulation of endothelial cell proliferation [IDA]
- regulation of satellite cell proliferation [IDA]
- sprouting angiogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FBLN7
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1.
Glioblastoma (GBM) is pathologically characterized by highly malignant neoplastic cells, focal necrosis and aberrant blood vessels composed of disorganized endothelial cells and pericytes. The recent cancer microarray database revealed upregulation of fibulin-7 (Fbln7), a member of the fibulin family, but provided no information on the tissue localization or biological function. In the present study, we demonstrated that Fbln7 is markedly ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID