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BAIT

NUMB

C14orf41, S171, c14_5527

numb homolog (Drosophila)

Alzheimer's Disease Project

GO Process (7)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

Notch signaling pathway [TAS]

axon guidance [TAS]

lateral ventricle development [ISS]

negative regulation of protein localization to plasma membrane [IMP]

neuroblast division in subventricular zone [ISS]

positive regulation of cell migration [IGI, IMP]

positive regulation of neurogenesis [ISS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

clathrin-coated vesicle [IDA]

focal adhesion [IDA]

integral component of plasma membrane [TAS]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

VIM

CTRCT30, HEL113, RP11-124N14.1

vimentin

GO Process (4)

GO Function (7)

GO Component (9)

Gene Ontology Biological Process

apoptotic process [TAS]

cellular component disassembly involved in execution phase of apoptosis [TAS]

cellular component movement [TAS]

muscle filament sliding [TAS]

Gene Ontology Molecular Function

double-stranded RNA binding [IDA]
glycoprotein binding [IPI]
identical protein binding [IPI]
protein C-terminus binding [IPI]
protein binding [IPI]
scaffold protein binding [IPI]
structural constituent of cytoskeleton [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytoskeleton [IDA, TAS]

cytosol [IDA, TAS]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

intermediate filament [IDA]

intermediate filament cytoskeleton [IDA]

peroxisome [IDA]

plasma membrane [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Two novel human NUMB isoforms provide a potential link between development and cancer.

Karaczyn A, Bani-Yaghoub M, Tremblay R, Kubu C, Cowling R, Adams TL, Prudovsky I, Spicer D, Friesel R, Vary C, Verdi JM

We previously identified four functionally distinct human NUMB isoforms. Here, we report the identification of two additional isoforms and propose a link between the expression of these isoforms and cancer. These novel isoforms, NUMB5 and NUMB6, lack exon 10 and are expressed in cells known for polarity and migratory behavior, such as human amniotic fluid cells, glioblastoma and metastatic tumor ... [more]

Neural Dev Dec. 01, 2010; 5();31 [Pubmed: 21122105]

Throughput

Low Throughput

Curated By

BioGRID