SORL1
Gene Ontology Biological Process
- cell migration [ISO]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein oligomerization [ISO]
- positive regulation of ER to Golgi vesicle-mediated transport [ISO]
- positive regulation of early endosome to recycling endosome transport [ISO]
- positive regulation of endocytic recycling [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein exit from endoplasmic reticulum [ISO]
- positive regulation of protein localization to early endosome [ISO]
- post-Golgi vesicle-mediated transport [ISO]
- protein maturation [ISO]
- protein retention in Golgi apparatus [ISO]
- protein targeting [ISO]
- protein targeting to Golgi [ISO]
- protein targeting to lysosome [ISO]
- regulation of smooth muscle cell migration [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi cisterna [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- multivesicular body [ISO]
- neuronal cell body [ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
EPHA4
Gene Ontology Biological Process
- adult walking behavior [IMP]
- axon guidance [IGI, IMP]
- corticospinal tract morphogenesis [IMP]
- ephrin receptor signaling pathway [IMP]
- fasciculation of motor neuron axon [IMP]
- fasciculation of sensory neuron axon [IMP]
- glial cell migration [ISO]
- motor neuron axon guidance [IMP]
- negative regulation of axon regeneration [IMP, ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- protein autophosphorylation [ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of Rap GTPase activity [IMP]
- regulation of Rho GTPase activity [ISO]
- regulation of astrocyte differentiation [IMP]
- regulation of axonogenesis [IMP]
- regulation of dendritic spine morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axon [IDA]
- axon terminus [ISO]
- axonal growth cone [ISO]
- cell body [ISO]
- cell projection [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [IDA, ISO]
- dendritic spine [ISO]
- early endosome membrane [IDA]
- endoplasmic reticulum [ISO]
- filopodium [ISO]
- integral component of plasma membrane [IDA, ISO]
- mitochondrial outer membrane [ISO]
- neuromuscular junction [ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain unclear. Here, we show that cultured transgenic neurons overexpressing SORLA feature longer neurites, and accelerated neurite regeneration with wounding. Enhanced release of a soluble form of SORLA (sSORLA) is observed in transgenic mouse neurons overexpressing human SORLA, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID