BAIT
SORL1
2900010L19Rik, AI596264, AW261561, LR11, SorLA, gp250, mSorLA
sortilin-related receptor, LDLR class A repeats-containing
GO Process (19)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- cell migration [ISO]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein oligomerization [ISO]
- positive regulation of ER to Golgi vesicle-mediated transport [ISO]
- positive regulation of early endosome to recycling endosome transport [ISO]
- positive regulation of endocytic recycling [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein exit from endoplasmic reticulum [ISO]
- positive regulation of protein localization to early endosome [ISO]
- post-Golgi vesicle-mediated transport [ISO]
- protein maturation [ISO]
- protein retention in Golgi apparatus [ISO]
- protein targeting [ISO]
- protein targeting to Golgi [ISO]
- protein targeting to lysosome [ISO]
- regulation of smooth muscle cell migration [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi cisterna [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- multivesicular body [ISO]
- neuronal cell body [ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
NTRK2
GP145-TrkB/GP95-TrkB, Tkrb, trk-B, trkB
neurotrophic tyrosine kinase, receptor, type 2
GO Process (37)
GO Function (8)
GO Component (23)
Gene Ontology Biological Process
- brain-derived neurotrophic factor receptor signaling pathway [IDA, ISO]
- calcium-mediated signaling using intracellular calcium source [IMP]
- central nervous system neuron development [IMP]
- cerebral cortex development [IMP]
- feeding behavior [IMP]
- glutamate secretion [IPI]
- learning [IMP]
- long-term memory [ISO]
- long-term synaptic potentiation [IMP]
- mechanoreceptor differentiation [IMP]
- negative regulation of anoikis [IDA]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular junction development [IMP]
- neuron differentiation [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IDA, ISO]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- peripheral nervous system neuron development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of axonogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- regulation of MAPK cascade [ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of dendrite development [ISO]
- regulation of metabolic process [IMP]
- regulation of neurotransmitter secretion [ISO]
- regulation of protein kinase B signaling [IMP]
- retinal rod cell development [IMP]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- axon terminus [ISO]
- cell [IPI]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [IDA]
- dendrite [ISO]
- dendritic spine [ISO]
- endosome [IDA]
- excitatory synapse [ISO]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IMP]
- neuronal cell body [ISO]
- neuronal postsynaptic density [IDA]
- perikaryon [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone [ISO]
- receptor complex [ISO]
- rough endoplasmic reticulum [ISO]
- terminal bouton [IDA]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain unclear. Here, we show that cultured transgenic neurons overexpressing SORLA feature longer neurites, and accelerated neurite regeneration with wounding. Enhanced release of a soluble form of SORLA (sSORLA) is observed in transgenic mouse neurons overexpressing human SORLA, ... [more]
J Neurosci Dec. 29, 2019; 40(31);5908-5921 [Pubmed: 32601248]
Throughput
- Low Throughput
Curated By
- BioGRID