BAIT
SORL1
2900010L19Rik, AI596264, AW261561, LR11, SorLA, gp250, mSorLA
sortilin-related receptor, LDLR class A repeats-containing
GO Process (19)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- cell migration [ISO]
- negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein oligomerization [ISO]
- positive regulation of ER to Golgi vesicle-mediated transport [ISO]
- positive regulation of early endosome to recycling endosome transport [ISO]
- positive regulation of endocytic recycling [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein exit from endoplasmic reticulum [ISO]
- positive regulation of protein localization to early endosome [ISO]
- post-Golgi vesicle-mediated transport [ISO]
- protein maturation [ISO]
- protein retention in Golgi apparatus [ISO]
- protein targeting [ISO]
- protein targeting to Golgi [ISO]
- protein targeting to lysosome [ISO]
- regulation of smooth muscle cell migration [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi cisterna [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- multivesicular body [ISO]
- neuronal cell body [ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
Mus musculus
PREY
ERBB2
Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu, mKIAA3023, RP23-355L10.8
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
GO Process (35)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [ISO]
- estrus [ISO]
- glial cell differentiation [ISO]
- heart development [IMP]
- motor neuron axon guidance [IMP]
- myelination [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of immature T cell proliferation in thymus [IMP]
- nervous system development [IMP]
- neuromuscular junction development [IMP]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- peripheral nervous system development [IMP, ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase I promoter [ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [ISO]
- protein autophosphorylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of microtubule-based process [ISO]
- response to axon injury [ISO]
- signal transduction [ISO]
- sympathetic nervous system development [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome membrane [ISO]
- integral component of membrane [NAS]
- lateral loop [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- receptor complex [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain unclear. Here, we show that cultured transgenic neurons overexpressing SORLA feature longer neurites, and accelerated neurite regeneration with wounding. Enhanced release of a soluble form of SORLA (sSORLA) is observed in transgenic mouse neurons overexpressing human SORLA, ... [more]
J Neurosci Dec. 29, 2019; 40(31);5908-5921 [Pubmed: 32601248]
Throughput
- Low Throughput
Curated By
- BioGRID