BAIT

SCNN1B

BESC1, ENaCb, ENaCbeta, SCNEB, hCG_23853
sodium channel, non-voltage-gated 1, beta subunit
Homo sapiens
PREY

HECW1

NEDL1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
UPS Project
GO Process (1)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Far Western

An interaction is detected between a protein immobilized on a membrane and a purified protein probe.

Publication

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

Harvey KF, Dinudom A, Cook DI, Kumar S

The amiloride-sensitive epithelial sodium channel (ENaC) plays a critical role in fluid and electrolyte homeostasis and consists of alpha, beta, and gamma subunits. The carboxyl terminus of each ENaC subunit contains a PPxY, motif which is believed to be important for interaction with the WW domains of the ubiquitin-protein ligase, Nedd4. Disruption of this interaction, as in Liddle's syndrome, where ... [more]

J. Biol. Chem. Mar. 16, 2001; 276(11);8597-601 [Pubmed: 11244092]

Throughput

  • Low Throughput

Curated By

  • BioGRID