BAIT
SOSTDC1
ECTODIN, USAG1, CDA019
sclerostin domain containing 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
TACC1
Ga55
transforming, acidic coiled-coil containing protein 1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.
The mechanistic basis of liver metastasis in colorectal cancer remains poorly understood. We previously reported that the sclerostin domain containing-1 (SOSTDC1) protein is overexpressed in the secretome of metastatic colorectal cancer cells and can inhibit liver homing. Here, we investigated the mechanisms of SOSTDC1 for promoting invasiveness and progression of colorectal cancer liver metastasis. SOSTDC1 inhibition of BMP4 maintains the ... [more]
Oncogene Dec. 01, 2019; 39(38);6085-6098 [Pubmed: 32801337]
Throughput
- Low Throughput
Curated By
- BioGRID