PPIF
Gene Ontology Biological Process
- cellular response to arsenic-containing substance [ISS]
- cellular response to calcium ion [ISS]
- cellular response to hydrogen peroxide [IMP]
- negative regulation of ATPase activity [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of oxidative phosphorylation [ISS]
- negative regulation of oxidative phosphorylation uncoupler activity [ISS]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of release of cytochrome c from mitochondria [ISS]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of mitochondrial membrane permeability [ISS]
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [IMP]
- regulation of proton-transporting ATPase activity, rotational mechanism [ISS]
- response to ischemia [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC25A4
Gene Ontology Biological Process
- adenine transport [TAS]
- energy reserve metabolic process [TAS]
- generation of precursor metabolites and energy [TAS]
- mitochondrial genome maintenance [TAS]
- negative regulation of necroptotic process [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore.
Opening of the mitochondrial permeability transition pore (MPTP) is sensitized to [Ca(2+)] by oxidative stress (diamide) and phenylarsine oxide (PAO). We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) binding. Here, we demonstrate that blocking Cys(160) with 80 microM eosin 5-maleimide (EMA) or 500 microM N-ethylmaleimide (NEM) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID