BAIT
A2M
A2MD, CPAMD5, FWP007, S863-7
alpha-2-macroglobulin
GO Process (10)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IL4
BCGF-1, BCGF1, BSF-1, BSF1, IL-4
interleukin 4
GO Process (26)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- B cell activation [IBA]
- B cell differentiation [TAS]
- T-helper 2 cell cytokine production [IDA]
- cellular defense response [TAS]
- chemotaxis [TAS]
- cholesterol metabolic process [ISS]
- connective tissue growth factor biosynthetic process [TAS]
- dendritic cell differentiation [IDA]
- immune response [TAS]
- negative regulation of apoptotic process [ISS]
- negative regulation of osteoclast differentiation [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of B cell proliferation [ISS]
- positive regulation of MHC class II biosynthetic process [ISS]
- positive regulation of T cell differentiation [IDA]
- positive regulation of T cell proliferation [ISS]
- positive regulation of interleukin-13 production [IDA]
- positive regulation of isotype switching to IgE isotypes [ISS]
- positive regulation of isotype switching to IgG isotypes [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of immune response [ISS]
- regulation of isotype switching [TAS]
- regulation of phosphorylation [ISS]
- type 2 immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interleukin-4 and IL-10 bind covalently to activated human alpha2-macroglobulin by a mechanism that requires Cys949.
Alpha2-macroglobulin (alpha2M) functions as an extracellular carrier of diverse cytokines, including transforming growth factor-beta1 (TGF-beta1), that expresses anti-inflammatory activities. The results presented here demonstrate that interleukin-10 (IL-10) and IL-4, which also regulate the inflammatory response, bind to alpha2M. Unlike TGF-beta, IL-4 and IL-10 bind almost exclusively to the receptor-recognized, or activated, form of alpha2M. Purified IL-4-alpha2M complexes were predominantly covalent ... [more]
J. Interferon Cytokine Res. Feb. 01, 2000; 20(2);125-31 [Pubmed: 10714547]
Throughput
- Low Throughput
Curated By
- BioGRID