BAIT
PPP1R9B
PPP1R6, PPP1R9, SPINO, Spn
protein phosphatase 1, regulatory subunit 9B
GO Process (11)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- RNA splicing [NAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- cellular response to morphine [ISS]
- filopodium assembly [IMP]
- negative regulation of catalytic activity [NAS]
- negative regulation of cell growth [IDA]
- regulation of cell growth by extracellular stimulus [TAS]
- regulation of cell proliferation [NAS]
- regulation of exit from mitosis [NAS]
- regulation of opioid receptor signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADRA2B
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR
adrenoceptor alpha 2B
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of MAPK activity by adrenergic receptor signaling pathway [IDA]
- activation of protein kinase B activity [IDA]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IDA]
- negative regulation of epinephrine secretion [NAS]
- negative regulation of norepinephrine secretion [NAS, TAS]
- platelet activation [TAS]
- positive regulation of neuron differentiation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.
Previously, we demonstrated that the third intracellular (3i) loop of the heptahelical alpha2A-adrenergic receptor (alpha2A AR) is critical for retention at the basolateral surface of polarized Madin-Darby canine kidney II (MDCKII) cells following their direct targeting to this surface. Findings that the 3i loops of the D2 dopamine receptors interact with spinophilin (Smith, F. D., Oxford, G. S., and Milgram, ... [more]
J. Biol. Chem. May. 04, 2001; 276(18);15003-8 [Pubmed: 11154706]
Throughput
- Low Throughput
Curated By
- BioGRID