DUSP4
Gene Ontology Biological Process
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- endoderm formation [IBA]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- protein dephosphorylation [IBA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [TAS]
MAPK14
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular component movement [TAS]
- cellular response to ionizing radiation [IMP]
- cellular response to lipopolysaccharide [IDA]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- chemotaxis [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- mRNA metabolic process [TAS]
- muscle cell differentiation [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoclast differentiation [ISS]
- p38MAPK cascade [ISS]
- peptidyl-serine phosphorylation [ISS]
- platelet activation [TAS]
- positive regulation of blood vessel endothelial cell migration [IMP]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myoblast fusion [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- signal transduction [TAS]
- signal transduction in response to DNA damage [IMP]
- stress-activated MAPK cascade [TAS]
- stress-induced premature senescence [IMP]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.
MKP-2 is a member of the mitogen-activated protein (MAP) kinase phosphatase family which has been suggested to play an important role in the feedback control of MAP kinase-mediated gene expression. Although MKP-2 preferentially inactivates extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK) MAP kinase subfamilies, the mechanisms underlying its own regulation remain unclear. In this report, we have examined ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DUSP4 MAPK14 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| DUSP4 MAPK14 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2215873 |
Curated By
- BioGRID