BAIT
THBS1
THBS, THBS-1, TSP, TSP-1, TSP1
thrombospondin 1
GO Process (60)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- activation of MAPK activity [IMP]
- behavioral response to pain [ISS]
- blood coagulation [TAS]
- cell adhesion [NAS]
- cell cycle arrest [IDA]
- cell migration [IDA]
- cellular response to heat [NAS]
- chronic inflammatory response [IEP]
- engulfment of apoptotic cell [IDA]
- extracellular matrix organization [TAS]
- immune response [IEP]
- negative regulation of angiogenesis [IDA]
- negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cGMP-mediated signaling [IDA]
- negative regulation of cell-matrix adhesion [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell antigen processing and presentation [IDA]
- negative regulation of endothelial cell chemotaxis [IDA]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of endothelial cell proliferation [IDA, IMP]
- negative regulation of extrinsic apoptotic signaling pathway [TAS]
- negative regulation of fibrinolysis [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA]
- negative regulation of focal adhesion assembly [TAS]
- negative regulation of interleukin-12 production [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of plasma membrane long-chain fatty acid transport [IDA]
- negative regulation of plasminogen activation [IDA]
- peptide cross-linking [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood coagulation [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of chemotaxis [IDA]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of fibroblast migration [IDA]
- positive regulation of macrophage activation [IDA]
- positive regulation of macrophage chemotaxis [ISS]
- positive regulation of phosphorylation [IMP]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of transforming growth factor beta1 production [ISS]
- positive regulation of translation [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- regulation of cGMP metabolic process [IDA]
- response to calcium ion [IDA]
- response to drug [IEP]
- response to endoplasmic reticulum stress [ISS]
- response to glucose [IDA]
- response to hypoxia [NAS]
- response to magnesium ion [IDA]
- response to progesterone [TAS]
- sprouting angiogenesis [IMP]
Gene Ontology Molecular Function- calcium ion binding [NAS]
- collagen V binding [IDA]
- fibrinogen binding [IDA]
- fibroblast growth factor binding [IDA]
- fibronectin binding [IDA]
- glycoprotein binding [NAS]
- heparin binding [IDA]
- identical protein binding [NAS]
- integrin binding [IMP]
- laminin binding [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- proteoglycan binding [TAS]
- transforming growth factor beta binding [ISS, TAS]
- calcium ion binding [NAS]
- collagen V binding [IDA]
- fibrinogen binding [IDA]
- fibroblast growth factor binding [IDA]
- fibronectin binding [IDA]
- glycoprotein binding [NAS]
- heparin binding [IDA]
- identical protein binding [NAS]
- integrin binding [IMP]
- laminin binding [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- proteoglycan binding [TAS]
- transforming growth factor beta binding [ISS, TAS]
Gene Ontology Cellular Component
- cell surface [IDA]
- endoplasmic reticulum [ISS]
- external side of plasma membrane [IDA]
- extracellular matrix [IDA, ISS, TAS]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- fibrinogen complex [IDA]
- platelet alpha granule [IDA]
- platelet alpha granule lumen [TAS]
- sarcoplasmic reticulum [ISS]
- secretory granule [IDA]
Homo sapiens
PREY
ITGB3
BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GO Process (36)
GO Function (9)
GO Component (16)
Gene Ontology Biological Process
- activation of protein kinase activity [IMP]
- angiogenesis involved in wound healing [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP]
- cell-substrate adhesion [IMP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [IDA, TAS]
- leukocyte migration [TAS]
- mesodermal cell differentiation [IEP]
- negative chemotaxis [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- platelet activation [IMP, TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein folding [IDA]
- regulation of bone resorption [TAS]
- smooth muscle cell migration [IMP]
- substrate adhesion-dependent cell spreading [IDA]
- tube development [TAS]
- viral entry into host cell [IMP]
- wound healing [IC]
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
Gene Ontology Cellular Component
- alphav-beta3 integrin-vitronectin complex [TAS]
- cell surface [IDA]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [TAS]
- integrin alphav-beta3 complex [IDA]
- integrin complex [IDA]
- lamellipodium membrane [IDA]
- melanosome [IDA]
- microvillus membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- platelet alpha granule membrane [TAS]
- receptor complex [IDA]
- ruffle membrane [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin.
The members of the integrin family of membrane glycoprotein heterodimer complexes function as cell surface receptors for adhesive proteins. We report here on the identification of two integrins on the surface of human platelets that bind to thrombospondin. When platelet membrane proteins are radiolabeled with 125I-lactoperoxidase, solubilized in n-octylglucoside, (Boehringer Mannheim Biochemicals, Indianapolis, IN), and applied to a column of ... [more]
Blood Nov. 01, 1989; 74(6);2022-7 [Pubmed: 2478219]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITGB3 THBS1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID