MAPK14
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- angiogenesis [IMP]
- cartilage condensation [IMP]
- cell morphogenesis [IGI]
- cellular response to DNA damage stimulus [IDA]
- cellular response to ionizing radiation [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- chondrocyte differentiation [IDA, IMP]
- fatty acid oxidation [IMP]
- glucose metabolic process [IMP]
- intracellular signal transduction [IDA, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- myoblast differentiation involved in skeletal muscle regeneration [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- osteoclast differentiation [IMP]
- p38MAPK cascade [IDA]
- peptidyl-serine phosphorylation [IDA]
- placenta development [IMP]
- positive regulation of brown fat cell differentiation [IMP]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of myoblast fusion [IMP]
- positive regulation of myotube differentiation [IMP]
- positive regulation of protein import into nucleus [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IMP]
- signal transduction in response to DNA damage [ISO]
- skeletal muscle tissue development [IMP]
- stress-activated MAPK cascade [ISO]
- stress-induced premature senescence [ISO]
- striated muscle cell differentiation [IGI]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP2K3
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- innate immune response [TAS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.
Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) is the archetypal member of the dual-specificity protein phosphatase family, the expression of which can be rapidly induced by a variety of growth factors and cellular stress. Since MKP-1 protein localizes in the nucleus, it has been suggested to play an important role in the feedback control of MAP kinase-regulated gene transcription. Recently it ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID