An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.

Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T

The ADF (actin-depolymerizing factor)/cofilin family is a stimulus-responsive mediator of actin dynamics. In contrast to the mechanisms of inactivation of ADF/cofilin by kinases such as LIM-kinase 1 (LIMK1), much less is known about its reactivation through dephosphorylation. Here we report Slingshot (SSH), a family of phosphatases that have the property of F actin binding. In Drosophila, loss of ssh function ... [more]

Cell Jan. 25, 2002; 108(2);233-46 [Pubmed: 11832213]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

SSH1

Gene Ontology Biological Process

Gene Ontology Molecular Function

actin binding [IDA]phosphoprotein phosphatase activity [IDA, IMP]protein binding [IPI]protein tyrosine/serine/threonine phosphatase activity [IBA]

Gene Ontology Cellular Component

DSTN