LIMK1
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- compound eye development [IGI]
- establishment of imaginal disc-derived wing hair orientation [IMP]
- establishment of planar polarity [IMP]
- imaginal disc morphogenesis [IMP]
- neuron projection morphogenesis [IMP]
- protein phosphorylation [IDA, NAS]
- regulation of axonogenesis [IMP]
- synapse assembly [IMP]
- synaptic growth at neuromuscular junction [IMP]
Gene Ontology Molecular Function
CFL1
Gene Ontology Biological Process
- actin filament organization [IMP]
- cell projection organization [ISO]
- cellular component movement [IMP]
- cytoskeleton organization [ISO]
- establishment of cell polarity [IMP]
- mitotic cytokinesis [IMP]
- negative regulation of cell size [ISO]
- neural crest cell migration [IMP]
- neural fold formation [IMP]
- positive regulation of actin filament depolymerization [IMP]
- protein import into nucleus [ISO]
- protein phosphorylation [IDA]
- regulation of cell morphogenesis [ISO]
- regulation of dendritic spine morphogenesis [ISO]
- response to amino acid [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.
The ADF (actin-depolymerizing factor)/cofilin family is a stimulus-responsive mediator of actin dynamics. In contrast to the mechanisms of inactivation of ADF/cofilin by kinases such as LIM-kinase 1 (LIMK1), much less is known about its reactivation through dephosphorylation. Here we report Slingshot (SSH), a family of phosphatases that have the property of F actin binding. In Drosophila, loss of ssh function ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID