BAIT
APBB1
Fe65, Rir
amyloid beta (A4) precursor protein-binding, family B, member 1
GO Process (19)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- actin filament-based movement [NAS]
- axon guidance [IGI]
- cell cycle arrest [IDA]
- cellular response to DNA damage stimulus [IDA, ISO]
- double-strand break repair [IMP, ISO]
- extracellular matrix organization [IGI]
- histone H4 acetylation [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of neuron differentiation [IMP]
- negative regulation of thymidylate synthase biosynthetic process [IDA]
- neuron migration [IGI]
- positive regulation of DNA repair [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein stabilization [NAS]
- regulation of transcription, DNA-templated [IDA]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
APLP1
APLP
amyloid beta (A4) precursor-like protein 1
GO Process (5)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Using the yeast two hybrid system, a mouse embryo cDNA library was screened for proteins that interact with the C-terminus of the human beta-amyloid precursor protein (beta PP). A fusion protein was identified that interacts specifically with the cytoplasmic domain of beta PP and does not interact with the beta-amyloid region. The protein encoded by this partial mouse cDNA is ... [more]
Hum. Mol. Genet. Oct. 01, 1996; 5(10);1589-98 [Pubmed: 8894693]
Throughput
- Low Throughput
Curated By
- BioGRID