CD38
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- long term synaptic depression [ISO]
- metabolic process [IBA, ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of B cell proliferation [IDA, ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vasoconstriction [ISO]
- response to drug [ISO]
- response to hormone [ISO]
- response to hydroperoxide [ISO]
- response to hypoxia [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LCK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- T cell differentiation [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- dephosphorylation [ISO]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of T cell receptor signaling pathway [IBA]
- positive regulation of gamma-delta T cell differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- positive regulation of uterine smooth muscle contraction [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA, ISO]
- regulation of T cell receptor signaling pathway [IDA]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- release of sequestered calcium ion into cytosol [IDA]
- response to drug [ISO]
- response to hydrogen peroxide [ISO]
- response to mechanical stimulus [ISO]
- response to metal ion [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATPase binding [ISO]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- SH2 domain binding [ISO]
- antigen binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- ATPase binding [ISO]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- SH2 domain binding [ISO]
- antigen binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Direct interaction of the CD38 cytoplasmic tail and the Lck SH2 domain. Cd38 transduces T cell activation signals through associated Lck.
CD38 ligation has been shown to induce activation of intracellular signaling cascade in T lymphocytes through a Lck-dependent pathway. However, it is not clear how Lck initiates the CD38-mediated signaling process. In the present study, we showed that CD38 and Lck were physically associated through the cytoplasmic tail and the Src homology 2 domain, respectively. This was evidenced by coimmunoprecipitation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID