BAIT
C8A
complement component 8, alpha polypeptide
GO Process (4)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
CD59
16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
CD59 molecule, complement regulatory protein
GO Process (5)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identity of the segment of human complement C8 recognized by complement regulatory protein CD59.
CD59 antigen is a membrane glycoprotein that inhibits the activity of the C5b-9 membrane attack complex (MAC), thereby protecting human cells from lysis by human complement. The inhibitory function of CD59 derives from its capacity to interact with both the C8 and C9 components of MAC, preventing assembly of membrane-inserted C9 polymer. MAC-inhibitory activity of CD59 is species-selective and is ... [more]
J. Biol. Chem. Aug. 25, 1995; 270(34);19723-8 [Pubmed: 7544344]
Throughput
- Low Throughput
Curated By
- BioGRID