BAIT
XCL1
ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1
chemokine (C motif) ligand 1
GO Process (35)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cell-cell signaling [IDA]
- cellular response to interleukin-4 [ISS]
- cellular response to transforming growth factor beta stimulus [ISS]
- mature natural killer cell chemotaxis [IDA]
- negative regulation of CD4-positive, alpha-beta T cell proliferation [IDA]
- negative regulation of T cell cytokine production [IDA]
- negative regulation of T-helper 1 cell activation [IDA]
- negative regulation of T-helper 1 type immune response [IC]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-2 production [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neutrophil chemotaxis [TAS]
- positive regulation of B cell chemotaxis [ISS]
- positive regulation of CD4-positive, alpha-beta T cell proliferation [ISS]
- positive regulation of CD8-positive, alpha-beta T cell proliferation [IDA]
- positive regulation of T cell chemotaxis [IDA]
- positive regulation of T cell cytokine production [ISS]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of T-helper 1 cell cytokine production [ISS]
- positive regulation of T-helper 2 cell cytokine production [ISS]
- positive regulation of granzyme A production [IDA]
- positive regulation of granzyme B production [IDA]
- positive regulation of immunoglobulin production in mucosal tissue [ISS]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of leukocyte chemotaxis [ISS]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of thymocyte migration [ISS]
- positive regulation of transforming growth factor beta production [IDA]
- regulation of inflammatory response [IDA]
- release of sequestered calcium ion into cytosol [ISS]
- response to virus [IDA]
- signal transduction [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPA5
BIP, GRP78, HEL-S-89n, MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
GO Process (14)
GO Function (10)
GO Component (12)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- ER-associated ubiquitin-dependent protein catabolic process [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- maintenance of protein localization in endoplasmic reticulum [IMP]
- negative regulation of apoptotic process [IMP, TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cell migration [IMP]
- regulation of protein folding in endoplasmic reticulum [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- endoplasmic reticulum [IDA, IMP, TAS]
- endoplasmic reticulum chaperone complex [IDA]
- endoplasmic reticulum lumen [TAS]
- endoplasmic reticulum membrane [TAS]
- endoplasmic reticulum-Golgi intermediate compartment [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- membrane [IDA]
- midbody [IDA]
- nucleus [IDA, IMP]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.753470474 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.753470474, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID