IL6ST
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- interleukin-27-mediated signaling pathway [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- leukemia inhibitory factor signaling pathway [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-6-mediated signaling pathway [IDA]
- oncostatin-M-mediated signaling pathway [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of acute inflammatory response [IC]
- positive regulation of adaptive immune response [IC]
- positive regulation of cardiac muscle hypertrophy [TAS]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation vascular endothelial growth factor production [TAS]
- response to cytokine [IDA]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
Gene Ontology Cellular Component
PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
Stimulation of the IL-6R complex leads to Src homology domain containing tyrosine phosphatase 2 (SHP2) recruitment to the receptor subunit gp130 and its subsequent tyrosine phosphorylation. SHP2 is a two-SH2 domain-containing protein tyrosine phosphatase that is activated by many cytokines and growth factors. SHP2 counteracts the activation of transcription factors of the STAT family and the induction of IL-6-responsive genes. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL6ST PTPN11 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IL6ST PTPN11 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IL6ST PTPN11 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IL6ST PTPN11 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID