PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
PTK2B
Gene Ontology Biological Process
- activation of Janus kinase activity [IMP]
- angiogenesis [IBA]
- apoptotic process [TAS]
- bone resorption [ISS]
- cell surface receptor signaling pathway [IMP]
- cellular defense response [ISS]
- cellular response to retinoic acid [IMP]
- chemokine-mediated signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- integrin-mediated signaling pathway [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- long-term synaptic potentiation [ISS]
- marginal zone B cell differentiation [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of bone mineralization [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of myeloid cell differentiation [IMP]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of potassium ion transport [IDA]
- peptidyl-tyrosine autophosphorylation [IBA, ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of B cell chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of protein kinase activity [IMP]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- protein autophosphorylation [TAS]
- protein complex assembly [TAS]
- protein phosphorylation [TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of cell adhesion [IMP]
- regulation of cell shape [IMP]
- regulation of establishment of cell polarity [ISS]
- regulation of inositol trisphosphate biosynthetic process [ISS]
- regulation of macrophage chemotaxis [ISS]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of release of sequestered calcium ion into cytosol [ISS]
- response to stress [TAS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- tumor necrosis factor-mediated signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- apical dendrite [ISS]
- cell body [ISS]
- cytoplasm [IDA]
- cytosol [TAS]
- dendrite [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA]
- growth cone [ISS]
- lamellipodium [IDA]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. However, the mechanism whereby IL-6 inhibits Dex-induced ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTK2B PTPN11 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PTPN11 PTK2B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 303280 | |
| PTK2B PTPN11 | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - |
Curated By
- BioGRID