STRA6
Gene Ontology Biological Process
- adrenal gland development [IMP]
- alveolar primary septum development [IMP]
- artery morphogenesis [IMP]
- blood vessel development [IMP]
- cognition [IMP]
- developmental growth [IMP]
- diaphragm development [IMP]
- digestive tract morphogenesis [IMP]
- ductus arteriosus closure [IMP]
- ear development [IMP]
- embryonic camera-type eye formation [IMP]
- embryonic digestive tract development [IMP]
- eyelid development in camera-type eye [IMP]
- face morphogenesis [IMP]
- feeding behavior [IMP]
- female genitalia development [IMP]
- head development [IMP]
- head morphogenesis [IMP]
- heart development [IMP]
- kidney development [IMP]
- learning [IMP]
- lung alveolus development [IMP]
- lung development [IMP]
- lung vasculature development [IMP]
- neuromuscular process [IMP]
- nose morphogenesis [IMP]
- paramesonephric duct development [IMP]
- phototransduction, visible light [TAS]
- positive regulation of behavior [IMP]
- pulmonary artery morphogenesis [IMP]
- pulmonary valve morphogenesis [IMP]
- retinoid metabolic process [TAS]
- smooth muscle tissue development [IMP]
- uterus morphogenesis [IMP]
- ventricular septum development [IMP]
- vocal learning [IMP]
Gene Ontology Cellular Component
PTPN1
Gene Ontology Biological Process
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- actin cytoskeleton reorganization [IMP]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum unfolded protein response [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of insulin receptor signaling pathway [NAS]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISS]
- platelet activation [TAS]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- regulation of endocytosis [IDA]
- regulation of hepatocyte growth factor receptor signaling pathway [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of signal transduction [IMP]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.956060641 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.956060641, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STRA6 PTPN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9937 | BioGRID | 3293167 |
Curated By
- BioGRID