PTPN6
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- T cell costimulation [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell differentiation [IDA]
- cell proliferation [IDA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- negative regulation of cell proliferation [NAS]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- protein dephosphorylation [IDA]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
BLNK
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates.
Signaling through the B cell antigen receptor (BCR) is negatively regulated by the SH2 domain-containing protein-tyrosine phosphatase SHP-1, which requires association with tyrosine-phosphorylated proteins for activation. Upon BCR ligation, SHP-1 has been shown to associate with the BCR, the cytoplasmic protein-tyrosine kinases Lyn and Syk, and the inhibitory co-receptors CD22 and CD72. How SHP-1 is activated by BCR ligation and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID