PREY

PTPN1

PTP1B
protein tyrosine phosphatase, non-receptor type 1
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).

Liu F, Hill DE, Chernoff J

Protein tyrosine phosphatase 1B (PTP1B) is an abundant intracellular enzyme that is thought to act as a negative regulator of certain signaling pathways. The C terminus of PTP1B contains two proline-rich regions which conform to the canonical class II Src homology 3 domain binding motif, Pro-X-X-Pro-X-Arg. In this study, we establish that PTP1B interacts with Crk, Grb2, and p130(Cas) in ... [more]

J. Biol. Chem. Dec. 06, 1996; 271(49);31290-5 [Pubmed: 8940134]

Throughput

  • Low Throughput

Curated By

  • BioGRID